GHK NIGHT CREAM

GHK NIGHT CREAM

Regular price $198.00 Sale price$148.00
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GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM

GHK NIGHT CREAM

Retinoid-Free Overnight Renewal with GHK-Cu

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Estimated shipping: August 30–September 9

Regular price $198.00 Sale price $148.00

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Designed as a retinoid-free alternative for visible age support, this biomimetic night cream delivers regenerative signals without the dryness, peeling, or acclimation period associated with more abrasive renewal treatments.

GHK-Cu is a powerful signaling tripeptide that is widely researched for its role in visible skin renewal, firmness, elasticity, hydration, and the appearance of age-related skin changes. In a randomized, double-blind trial over 8 weeks, topical GHK-Cu reduced wrinkle volume by 31.6% versus a leading peptide comparator and 55.8% versus a control serum.  In a 20-person head-to-head with tretinoin, skin samples showed 7 out of 10 people were producing more new collagen after one month of using a copper-peptide cream versus 5 out of 10 in the tretinoin group. 

Research on GHK-Cu has explored its relationship to collagen, elastin, wound-healing pathways, antioxidant defense, hair regrowth, and skin remodeling biology. 

GHK-Cu is not a trend. It is a naturally occurring copper peptide your body recognizes and one that declines with age. Our biomimetic night cream returns this skin-familiar signal to your ritual for visibly firmer, smoother, more resilient-looking skin.

Refrigeration is required for maximum efficacy/longevity of the peptide. 

WHAT IT DOES

Targets the visible signs of aging while you sleep, helping improve the look of firmness, elasticity, texture, hydration, and overall resilience. Skin wakes feeling deeply conditioned and looking smoother, stronger, and more rested without the dryness, peeling, or acclimation period associated with retinoids.

WHY IT WORKS

GHK-Cu is a naturally occurring copper peptide that acts as a skin-familiar signaling molecule and has been widely studied in connection with collagen, elastin, antioxidant defense, wound-healing pathways, and skin-remodeling biology. Paired with ceramides, ectoin, and low-molecular-weight hyaluronic acid, it supports visible renewal while reinforcing hydration and barrier comfort throughout the night.

PRODUCT DETAILS

Texture: rich, blue copper-peptide cream
Finish: silky, nourished, comforted, restored
Fragrance: none
Product Material: Matte-Black Rigid AS Resin Airless Pump
Storage Requirements: Refrigeration Required
Size: 1.7 oz | 50 mL
Vegan: Yes
Made Safe Compliant: Yes
Packaging: All Products arrive wrapped in a 100% Cotton Reusable Draw-String Keepsake bag.

HOW TO USE

In the evening, apply to face and neck as the final step after cleansing, hypochlorous acid mist, Hydrating Peptide Toner, and serums. We recommend starting conservatively at 2x a week to ease in to the use of this peptide. It is very powerful and works very quickly at sending signals to your collagen. If you are also starting the Recover Serum, use these products on different days to start until you know how your skin reacts to signal peptides.

INGREDIENTS

Aqua (Water), Squalane, Caprylic/Capric Triglyceride, Dicaprylyl Carbonate, Cetearyl Alcohol, Glycerin, Propanediol, Niacinamide, Betaine, Panthenol, Bis-Diglyceryl Polyacyladipate-2, Ectoin, Copper Tripeptide-1, Sclerotium Gum, Cetearyl Glucoside, Phenoxyethanol, Ethylhexylglycerin, Lactic Acid.

Pairs well with
CRYSTAL PDRN GLASS SERUM

CRYSTAL PDRN GLASS SERUM

Regular price $98.00 Sale price$78.00
RECOVER-ME 3S CORRECTV COMPLEX

RECOVER-ME 3S CORRECTV COMPLEX

Regular price $128.00 Sale price$96.00
RECOVER-ME BARRIER CREAM

RECOVER-ME BARRIER CREAM

Regular price $108.00 Sale price$78.00

GHK NIGHT CREAM

Made for skin experiencing

An overnight renewal cream for skin showing visible signs of aging, fatigue, and reduced regenerative capacity.

Fine Lines

Loss of Firmness

Compromised Barrier

Visible Signs of Aging

Visible Fatigue

Loss of Density

THE DAILY RITUAL

Where it fits.

01

Cleanse

Barrier Cleanser

02

Polish

Enzyme + PHA Polish

03

Tone

EGCG + PAD Toner

04

Treat

Recover-Me 3S CORRECTV

05

Seal

Barrier Cream

Advanced overnight peptide treatment

Give Skin Better Instructions.

Signal. Rebuild. Renew.

A concentrated overnight treatment powered by GHK-Cu to support visible firmness, refined texture and stronger-looking skin while biomimetic lipids and comfort actives reinforce the barrier through the night.

Copper peptide signaling system

Final step of the evening ritual

02

Rebuild

Ceramides · Ectoin · Barrier Lipids

Helps restore the lipid structure skin relies on to retain moisture and remain resilient throughout overnight recovery.

03

Renew

Cushioned Overnight Recovery

Maintains a comfortable, moisture-supported environment while skin moves through its natural nighttime renewal cycle.

Cold-stored formula

Refrigeration helps protect formula integrity and preserves the intended overnight treatment experience.

0.25%
GHK-Cu
Copper peptide signaling
Signal
Visible Firmness
Supports refined texture and stronger-looking skin
Rebuild
Barrier Lipids
Overnight resilience and moisture retention
Cold-Stored
Formula Integrity
Refrigerated overnight treatment

Designed for consistent overnight use to support visible improvements in firmness, texture and overall skin quality.

Loved by our Alchemy community

"I've never seen changes like this in my skin from a topical. My skin is brighter, clearer, and firmer all over and my melasma is non-existent. It took some time to get used to using the product, and I took it very slow. I even took a week off when I traveled and I still continued to have day to day changes. I use it 2-3 times a week now for maintenance." - Kelley, 46

The Science of Overnight Renewal

The peptide that changes the conversation around aging.

GHK-Cu is not simply a surface-conditioning ingredient. It is a naturally occurring copper peptide studied for its relationship with repair signaling, matrix remodeling and the structural systems that help skin look firmer, smoother and more resilient.

Copper Peptide Concentration

A deliberate level of regenerative signaling.

GHK-Cu is a naturally occurring copper-binding tripeptide studied for its role in skin remodeling, extracellular-matrix support, repair signaling and antioxidant defense.

Formulated with 0.25% GHK-Cu in the finished GHK Night Cream. This level is backed by research to provide the lowest effective dose with maximum benefit and least discomfort. More isn't better with this peptide. The right amount and structuring it intelligently into a routine is the difference between transformation that lasts and a product that over-shoots its promise and breaks down faster than it rebuilds.

01

Matrix Remodeling

Studied for supporting collagen, elastin, glycosaminoglycans and decorin, structural components associated with resilient-looking skin.

02

Firmness + Elasticity

Controlled research summarized in the scientific literature has associated topical GHK-Cu with improvements in firmness, elasticity and the appearance of fine lines.

03

Repair Signaling

GHK-Cu has been studied for its influence on fibroblast activity, tissue repair and the coordinated synthesis and breakdown involved in healthy matrix renewal.

04

Antioxidant Defense

Laboratory and preclinical research describes antioxidant and inflammation-modulating activity that may help support the skin’s response to environmental stress.

Research references

Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences. 2018.

Dou Y, Lee A, Zhu L, Morton J, Ladiges W. The potential of GHK as an anti-aging peptide. Aging Pathobiology and Therapeutics. 2020.

Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International. 2015.

Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Letters. 1988.

Research discussed in this section evaluates GHK or GHK-Cu across laboratory, ex vivo, preclinical and human cosmetic settings. These studies did not evaluate the finished Alchemy 21/12 GHK Night Cream. Individual results may vary.

THE COPPER SIGNAL

GHK Night Cream, explained.

What GHK-Cu is, how it fits into the ritual, and how to protect the formula's performance.

What is GHK-Cu?

GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycine, histidine, and lysine. In skincare research, it has been studied for its role in processes associated with visible recovery, extracellular-matrix support, collagen production, antioxidant defense, and tissue remodeling.

In GHK Night Cream, it functions as a concentrated nighttime signal inside a complete barrier-supportive formula.

What does GHK Night Cream do for the look of skin?

GHK Night Cream is designed for skin that looks depleted, less firm, uneven in texture, or slower to recover. Its copper-peptide signal is paired with ceramides, ectoin, and hydration support to help skin look smoother, stronger, more resilient, and visibly restored over time.

Why is the cream blue?

The blue color comes naturally from the copper-peptide complex. It is not an added dye, and it does not mean the formula has oxidized.

The color should disappear as the cream is spread into a thin, even layer.

Why did Alchemy 21/12 use 0.25% GHK-Cu?

We use GHK-Cu at 0.25% as a deliberate, concentrated nighttime signal within a complete barrier-supportive cream. More is not automatically better with signaling ingredients.

The goal is a meaningful amount in a balanced formula that skin can use consistently, rather than building the product around the highest possible number.

Why should GHK Night Cream be refrigerated?

GHK Night Cream should be stored in the refrigerator to help preserve the finished formula's intended stability and performance.

Keep it chilled, close the container promptly after use, and avoid leaving it in direct light or prolonged heat.

When should I use it?

Use GHK Night Cream in the evening as the final step of your nighttime ritual.

Cleanse → Toner → Recover-Me 3S CORRECTV Complex → GHK Night Cream.

Allow the preceding serum layer to settle before applying the cream.

How much should I apply?

Begin with one pump for the face and add a small amount for the neck and décolletage as needed.

More product does not create a stronger copper-peptide signal. A thin, even layer is enough.

Can I use GHK Night Cream every night?

Yes, once your skin has adjusted to it. If your skin is reactive, or if you are introducing several concentrated Alchemy formulas at the same time, begin two or three evenings weekly and increase according to comfort.

Can sensitive skin use copper peptides?

Many people tolerate topical copper peptides well, but any concentrated active can cause redness, itching, or irritation in some skin.

Patch test first, introduce the cream gradually, and stop using it if you experience persistent discomfort, swelling, or a worsening reaction.

Can I use it with vitamin C or exfoliating acids?

We recommend separating GHK Night Cream from strongly acidic L-ascorbic acid and low-pH exfoliating treatments.

Use vitamin C in the morning. Use Enzyme + PHA Resurfacing Polish on a separate evening. This keeps the ritual more controlled and avoids creating an unnecessarily reactive routine.

Is GHK Night Cream a moisturizer or a treatment?

It is both. The formula delivers a concentrated copper-peptide signal inside a night cream that also replenishes hydration and supports the lipid barrier.

That matters because signaling is only one part of visible recovery. Skin also needs water, lipids, and a stable environment in which to respond.

How is it different from Recover-Me Barrier Cream?

Recover-Me Barrier Cream is the daily barrier moisturizer. It focuses on replenishing moisture, reducing water loss, and maintaining calm, comfortable resilience.

GHK Night Cream is the more concentrated nighttime intervention. It adds the GHK-Cu signal to barrier and hydration support for skin showing more visible loss of firmness, texture refinement, or recovery capacity.

Barrier Cream protects the conditions. GHK Night Cream adds the nighttime signal.

How is it different from Recover-Me 3S CORRECTV Complex?

CORRECTV is a concentrated nighttime serum built around PDRN, Camellia-derived extracellular vesicles, and a multi-peptide corrective stack.

GHK Night Cream completes the ritual with copper-peptide signaling, ceramides, ectoin, and replenishing hydration. CORRECTV delivers the first corrective layer. GHK seals the ritual and adds its own distinct signal.

How long before I see results?

You may notice greater softness, hydration, and comfort within the first several uses. Visible improvements in firmness, texture, resilience, and the appearance of fine lines develop more gradually.

Human studies of topical GHK-Cu creams reported measurable improvements after 12 weeks of consistent use, including improvements in skin density, firmness, laxity, fine lines, and wrinkle depth.

Give the ritual 8 to 12 weeks to show you what it can do.

These studies evaluated GHK-Cu-containing creams rather than the finished Alchemy 21/12 formula. Individual results will vary.

Will it turn my skin blue?

No. The cream's blue color comes from the copper-peptide complex, but it should disappear as the product is spread into a thin, even layer.

Applying substantially more than directed may leave unnecessary visible residue.

Can I use it around my eyes?

Apply around the orbital bone rather than directly against the lash line or onto the eyelids. Avoid contact with the eyes.

If your eye area is highly reactive, introduce it cautiously.

Can I use it after professional treatments?

Do not assume that a concentrated peptide cream is appropriate immediately after a laser, peel, microneedling procedure, injectable treatment, or any procedure that temporarily compromises the skin.

Follow your practitioner's post-treatment instructions and reintroduce GHK Night Cream only after they have cleared active skincare.

Can I use it during pregnancy or breastfeeding?

Topical cosmetic copper peptides do not have a robust pregnancy-specific safety evidence base. Ask your obstetrician or medical provider before beginning any concentrated active product during pregnancy or breastfeeding.

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