Signal
GHK-Cu Copper Peptide
Supports the signaling environment associated with visible firmness, smoother texture and healthier-looking skin renewal.

Retinoid-Free Overnight Renewal with GHK-Cu
Estimated shipping: August 30–September 9
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Designed as a retinoid-free alternative for visible age support, this biomimetic night cream delivers regenerative signals without the dryness, peeling, or acclimation period associated with more abrasive renewal treatments.
GHK-Cu is a powerful signaling tripeptide that is widely researched for its role in visible skin renewal, firmness, elasticity, hydration, and the appearance of age-related skin changes. In a randomized, double-blind trial over 8 weeks, topical GHK-Cu reduced wrinkle volume by 31.6% versus a leading peptide comparator and 55.8% versus a control serum. In a 20-person head-to-head with tretinoin, skin samples showed 7 out of 10 people were producing more new collagen after one month of using a copper-peptide cream versus 5 out of 10 in the tretinoin group.
Research on GHK-Cu has explored its relationship to collagen, elastin, wound-healing pathways, antioxidant defense, hair regrowth, and skin remodeling biology.
GHK-Cu is not a trend. It is a naturally occurring copper peptide your body recognizes and one that declines with age. Our biomimetic night cream returns this skin-familiar signal to your ritual for visibly firmer, smoother, more resilient-looking skin.
Refrigeration is required for maximum efficacy/longevity of the peptide.
GHK NIGHT CREAM
An overnight renewal cream for skin showing visible signs of aging, fatigue, and reduced regenerative capacity.
Fine Lines
Loss of Firmness
Compromised Barrier
Visible Signs of Aging
Visible Fatigue
Loss of Density
THE DAILY RITUAL
Cleanse
Barrier Cleanser
Tone
EGCG + PAD Toner
Hydrate
Crystal PDRN Serum
Seal
Barrier Cream
Cleanse
Barrier Cleanser
Polish
Enzyme + PHA Polish
Tone
EGCG + PAD Toner
Treat
Recover-Me 3S CORRECTV
Seal
Barrier Cream
Renew
GHK Night Cream
Advanced overnight peptide treatment
Signal. Rebuild. Renew.
A concentrated overnight treatment powered by GHK-Cu to support visible firmness, refined texture and stronger-looking skin while biomimetic lipids and comfort actives reinforce the barrier through the night.
GHK-Cu Copper Peptide
Supports the signaling environment associated with visible firmness, smoother texture and healthier-looking skin renewal.
Copper peptide signaling system
Final step of the evening ritual
Ceramides · Ectoin · Barrier Lipids
Helps restore the lipid structure skin relies on to retain moisture and remain resilient throughout overnight recovery.
Cushioned Overnight Recovery
Maintains a comfortable, moisture-supported environment while skin moves through its natural nighttime renewal cycle.
Cold-stored formula
Refrigeration helps protect formula integrity and preserves the intended overnight treatment experience.
Designed for consistent overnight use to support visible improvements in firmness, texture and overall skin quality.
Loved by our Alchemy community
"I've never seen changes like this in my skin from a topical. My skin is brighter, clearer, and firmer all over and my melasma is non-existent. It took some time to get used to using the product, and I took it very slow. I even took a week off when I traveled and I still continued to have day to day changes. I use it 2-3 times a week now for maintenance." - Kelley, 46
The Science of Overnight Renewal
GHK-Cu is not simply a surface-conditioning ingredient. It is a naturally occurring copper peptide studied for its relationship with repair signaling, matrix remodeling and the structural systems that help skin look firmer, smoother and more resilient.
Copper Peptide Concentration
GHK-Cu is a naturally occurring copper-binding tripeptide studied for its role in skin remodeling, extracellular-matrix support, repair signaling and antioxidant defense.
Formulated with 0.25% GHK-Cu in the finished GHK Night Cream. This level is backed by research to provide the lowest effective dose with maximum benefit and least discomfort. More isn't better with this peptide. The right amount and structuring it intelligently into a routine is the difference between transformation that lasts and a product that over-shoots its promise and breaks down faster than it rebuilds.
Studied for supporting collagen, elastin, glycosaminoglycans and decorin, structural components associated with resilient-looking skin.
Controlled research summarized in the scientific literature has associated topical GHK-Cu with improvements in firmness, elasticity and the appearance of fine lines.
GHK-Cu has been studied for its influence on fibroblast activity, tissue repair and the coordinated synthesis and breakdown involved in healthy matrix renewal.
Laboratory and preclinical research describes antioxidant and inflammation-modulating activity that may help support the skin’s response to environmental stress.
Why GHK-Cu?
Many cosmetic ingredients are designed to hydrate the surface, accelerate exfoliation or temporarily improve texture. GHK-Cu has attracted scientific interest because it interacts with multiple processes associated with repair, structural renewal and the skin’s response to age-related stress.
The Research Landscape
GHK-Cu has been investigated in laboratory, ex vivo, preclinical and human cosmetic research. These evidence types answer different questions and should not be treated as interchangeable.
Laboratory
Cell and tissue models have been used to investigate collagen, elastin, glycosaminoglycan, decorin and fibroblast-related activity.
Ex Vivo
Human skin-tissue models help researchers study matrix proteins, peptide delivery and activity beyond isolated cell cultures.
Preclinical
Preclinical work has explored tissue remodeling, wound repair, oxidative stress and inflammation-related pathways.
Human Use
Published reviews describe controlled cosmetic research reporting improvements in firmness, elasticity, skin density and fine lines.
We distinguish research on GHK-Cu from testing of the finished GHK Night Cream. Ingredient research explains why the peptide was selected. It does not guarantee identical outcomes from every formula or for every person.
Repair. Regenerate. Restore.
GHK Night Cream pairs 0.25% GHK-Cu with ceramides, ectoin and low-molecular-weight hyaluronic acid in a refrigerated nighttime treatment designed to support smoother, firmer and more resilient-looking skin.
Pickart L, Margolina A. Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences. 2018.
Dou Y, Lee A, Zhu L, Morton J, Ladiges W. The potential of GHK as an anti-aging peptide. Aging Pathobiology and Therapeutics. 2020.
Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International. 2015.
Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Letters. 1988.
Research discussed in this section evaluates GHK or GHK-Cu across laboratory, ex vivo, preclinical and human cosmetic settings. These studies did not evaluate the finished Alchemy 21/12 GHK Night Cream. Individual results may vary.
THE COPPER SIGNAL
What GHK-Cu is, how it fits into the ritual, and how to protect the formula's performance.
GHK-Cu is a naturally occurring copper-binding tripeptide composed of glycine, histidine, and lysine. In skincare research, it has been studied for its role in processes associated with visible recovery, extracellular-matrix support, collagen production, antioxidant defense, and tissue remodeling.
In GHK Night Cream, it functions as a concentrated nighttime signal inside a complete barrier-supportive formula.
GHK Night Cream is designed for skin that looks depleted, less firm, uneven in texture, or slower to recover. Its copper-peptide signal is paired with ceramides, ectoin, and hydration support to help skin look smoother, stronger, more resilient, and visibly restored over time.
The blue color comes naturally from the copper-peptide complex. It is not an added dye, and it does not mean the formula has oxidized.
The color should disappear as the cream is spread into a thin, even layer.
We use GHK-Cu at 0.25% as a deliberate, concentrated nighttime signal within a complete barrier-supportive cream. More is not automatically better with signaling ingredients.
The goal is a meaningful amount in a balanced formula that skin can use consistently, rather than building the product around the highest possible number.
GHK Night Cream should be stored in the refrigerator to help preserve the finished formula's intended stability and performance.
Keep it chilled, close the container promptly after use, and avoid leaving it in direct light or prolonged heat.
Use GHK Night Cream in the evening as the final step of your nighttime ritual.
Cleanse → Toner → Recover-Me 3S CORRECTV Complex → GHK Night Cream.
Allow the preceding serum layer to settle before applying the cream.
Begin with one pump for the face and add a small amount for the neck and décolletage as needed.
More product does not create a stronger copper-peptide signal. A thin, even layer is enough.
Yes, once your skin has adjusted to it. If your skin is reactive, or if you are introducing several concentrated Alchemy formulas at the same time, begin two or three evenings weekly and increase according to comfort.
Many people tolerate topical copper peptides well, but any concentrated active can cause redness, itching, or irritation in some skin.
Patch test first, introduce the cream gradually, and stop using it if you experience persistent discomfort, swelling, or a worsening reaction.
We recommend separating GHK Night Cream from strongly acidic L-ascorbic acid and low-pH exfoliating treatments.
Use vitamin C in the morning. Use Enzyme + PHA Resurfacing Polish on a separate evening. This keeps the ritual more controlled and avoids creating an unnecessarily reactive routine.
It is both. The formula delivers a concentrated copper-peptide signal inside a night cream that also replenishes hydration and supports the lipid barrier.
That matters because signaling is only one part of visible recovery. Skin also needs water, lipids, and a stable environment in which to respond.
Recover-Me Barrier Cream is the daily barrier moisturizer. It focuses on replenishing moisture, reducing water loss, and maintaining calm, comfortable resilience.
GHK Night Cream is the more concentrated nighttime intervention. It adds the GHK-Cu signal to barrier and hydration support for skin showing more visible loss of firmness, texture refinement, or recovery capacity.
Barrier Cream protects the conditions. GHK Night Cream adds the nighttime signal.
CORRECTV is a concentrated nighttime serum built around PDRN, Camellia-derived extracellular vesicles, and a multi-peptide corrective stack.
GHK Night Cream completes the ritual with copper-peptide signaling, ceramides, ectoin, and replenishing hydration. CORRECTV delivers the first corrective layer. GHK seals the ritual and adds its own distinct signal.
You may notice greater softness, hydration, and comfort within the first several uses. Visible improvements in firmness, texture, resilience, and the appearance of fine lines develop more gradually.
Human studies of topical GHK-Cu creams reported measurable improvements after 12 weeks of consistent use, including improvements in skin density, firmness, laxity, fine lines, and wrinkle depth.
Give the ritual 8 to 12 weeks to show you what it can do.
These studies evaluated GHK-Cu-containing creams rather than the finished Alchemy 21/12 formula. Individual results will vary.
No. The cream's blue color comes from the copper-peptide complex, but it should disappear as the product is spread into a thin, even layer.
Applying substantially more than directed may leave unnecessary visible residue.
Apply around the orbital bone rather than directly against the lash line or onto the eyelids. Avoid contact with the eyes.
If your eye area is highly reactive, introduce it cautiously.
Do not assume that a concentrated peptide cream is appropriate immediately after a laser, peel, microneedling procedure, injectable treatment, or any procedure that temporarily compromises the skin.
Follow your practitioner's post-treatment instructions and reintroduce GHK Night Cream only after they have cleared active skincare.
Topical cosmetic copper peptides do not have a robust pregnancy-specific safety evidence base. Ask your obstetrician or medical provider before beginning any concentrated active product during pregnancy or breastfeeding.
Pre-order
The complete seven-step Alchemy Ritual for cleansing, resurfacing, layered hydration, regenerative signaling, barrier support, and overnight renewal.
What’s included
Barrier Cleanser
Recover-Me EGCG + PAD Toner
Enzyme + PHA Resurfacing Polish
Crystal PDRN Glass Serum
Recover-Me 3S Serum
Recover-Me Barrier Cream
GHK Night Cream
Essentials II brings the full morning-to-night ritual together in one comprehensive system. The seven formulas work in sequence to cleanse gently, refine texture, replenish hydration, support visible renewal, reinforce the barrier, and complete the routine with copper peptide-powered overnight care.
Used together, they help skin look smoother, calmer, stronger, more luminous, and visibly renewed over time.