GHK NIGHT CREAM

GHK NIGHT CREAM

Sale price$148.00
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GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM
GHK NIGHT CREAM

GHK NIGHT CREAM

Retinoid-Free 0.25% GHK Copper Peptide Night Cream

Sale price $148.00

In stock

GHK Night Cream is a 0.25% Copper Tripeptide-1 night cream engineered for high-performance overnight renewal without making irritation the price of admission. GHK is a powerful signaling tripeptide widely studied for its role in visible firmness, elasticity, skin remodeling and age-related change. We built it into a deliberately cushioned, comfort-first formula with squalane, ectoin, panthenol, betaine, niacinamide and humectants that support skin while the peptide does the deeper work.

The concentration matters. So does the formula around it. Rather than chasing the biggest percentage for the label, we formulated GHK Night Cream to deliver the most effective copper-peptide signal your skin needs in a system designed to be introduced gradually and used consistently. The result is an intensive corrective that can be remarkably gentle when used as intended: powerful enough to produce visible change, composed enough to earn a permanent place in your nighttime ritual.

And we don't hand you a potent active and leave you to figure it out. Every GHK Night Cream purchase is supported with clear introduction guidance, ongoing education and follow-up by email so you know how to ramp up, what to watch for, when to hold steady and how to integrate it with the rest of your routine. Copper peptides deserve more than a set of generic directions. We want you to understand what you're using and how to get the best from it.

GHK is not a trend. It is a naturally occurring copper peptide your body recognizes and one that declines with age. GHK Night Cream returns that skin-familiar signal to your ritual for visibly firmer, smoother, more resilient-looking skin, without retinoids and without treating discomfort as proof that a product is working.

If you're deciding between copper peptides and retinoids, read our comparison of GHK vs Retinol.

Refrigeration is required to help protect peptide integrity and formula longevity. A light blue or light purple hue is normal.

PRODUCT DETAILS

Texture: rich, blue copper-peptide cream
Finish: silky, nourished, comforted, restored
Fragrance: none
Product Material: Matte-Black Rigid AS Resin Airless Pump
Storage Requirements: Refrigeration Required
Size: 1.7 oz | 50 mL
Vegan: Yes
Developed to Made Safe Standards: Yes
Packaging: All Products arrive wrapped in a 100% Cotton Reusable Draw-String Keepsake bag.

HOW TO USE

In the evening, apply to face and neck as the final step after cleansing, toner, and serums. We recommend starting conservatively at 1–2 nights per week and increasing as your skin becomes comfortable with the formula. GHK is a powerful signal peptide, and this is an intensive corrective designed to be introduced deliberately. If you’re also starting Recover-Me 3S CORRECTV Complex, use them on different nights at first so you can see how your skin responds to each formula before bringing them into the same routine.

INGREDIENTS

Aqua (Water), Squalane, Caprylic/Capric Triglyceride, Dicaprylyl Carbonate, Cetearyl Alcohol, Glycerin, Propanediol, Niacinamide, Betaine, Panthenol, Ectoin, Copper Tripeptide-1, Bis-Diglyceryl Polyacyladipate-2, Cetearyl Glucoside, Sclerotium Gum, Phenoxyethanol, Ethylhexylglycerin, Lactic Acid.

JEN'S NOTE

GHK Night Cream is a focused copper-peptide treatment, not a second Barrier Cream. Use it when you want the deeper nighttime signal. Start at 1-2 nights per week on alternate nights from CORRECTV to allow your skin time to acclimate to the peptides.

Pairs well with
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CRYSTAL PDRN GLASS SERUM

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RECOVER-ME 3S CORRECTV COMPLEX

RECOVER-ME 3S CORRECTV COMPLEX

Sale price$108.00

GHK NIGHT CREAM

Made for skin experiencing

An overnight renewal cream for skin showing visible signs of aging, fatigue, and reduced regenerative capacity.

Fine Lines

Loss of Firmness

Compromised Barrier

Visible Signs of Aging

Visible Fatigue

Loss of Density

THE DAILY RITUAL

Where it fits.

01

Cleanse

Barrier Cleanser

02

Polish

Enzyme + PHA Polish

03

Tone

EGCG + PAD Toner

04

Treat

Recover-Me 3S CORRECTV

05

Seal

Barrier Cream

Advanced overnight peptide treatment

Give Skin Better Instructions.

Signal. Rebuild. Renew.

A concentrated overnight treatment powered by GHK to support visible firmness, refined texture and stronger-looking skin while biomimetic lipids and comfort actives reinforce the barrier through the night.

Copper peptide signaling system

Final step of the evening ritual

02

Rebuild

Niacinimide · Ectoin · Barrier Lipids

Helps restore the lipid structure skin relies on to retain moisture and remain resilient throughout overnight recovery.

03

Renew

Cushioned Overnight Recovery

Maintains a comfortable, moisture-supported environment while skin moves through its natural nighttime renewal cycle.

Cold-stored formula

Refrigeration helps protect formula integrity and preserves the intended overnight treatment experience.

0.25%
Copper Tripeptide-1
Copper peptide signaling
Signal
Visible Firmness
Supports refined texture and stronger-looking skin
Rebuild
Barrier Lipids
Overnight resilience and moisture retention
Cold-Stored
Formula Integrity
Refrigerated overnight treatment

Designed for consistent overnight use to support visible improvements in firmness, texture and overall skin quality.

Loved by our Alchemy community

"I've never seen changes like this in my skin from a topical. My skin is brighter, clearer, and firmer all over and my melasma is non-existent. It took some time to get used to using the product, and I took it very slow. I even took a week off when I traveled and I still continued to have day to day changes. I use it 2-3 times a week now for maintenance." - Kelley, 46

The Science of Overnight Renewal

The peptide that changes the conversation around aging.

GHK is not simply a surface-conditioning ingredient. It is a naturally occurring copper peptide studied for its relationship with repair signaling, matrix remodeling and the structural systems that help skin look firmer, smoother and more resilient.

Copper Peptide Concentration

A deliberate level of regenerative signaling.

GHK is a naturally occurring copper-binding tripeptide studied for its role in skin remodeling, extracellular-matrix support, repair signaling and antioxidant defense.

Formulated with 0.25% GHK in the finished GHK Night Cream, equal to roughly 395 ppm of copper. That level was chosen deliberately. Published laboratory research shows GHK follows a biphasic dose-response: activity rises, peaks, and then falls as concentration continues upward. We formulated at 0.25% to deliver a substantial copper-peptide signal in a cream built for nightly tolerability and consistent use. We formulated to the curve, not the marketing number.

01

Matrix Remodeling

Studied for supporting collagen, elastin, glycosaminoglycans and decorin, structural components associated with resilient-looking skin.

02

Firmness + Elasticity

Controlled research summarized in the scientific literature has associated topical GHK with improvements in firmness, elasticity and the appearance of fine lines.

03

Repair Signaling

GHK has been studied for its influence on fibroblast activity, tissue repair and the coordinated synthesis and breakdown involved in healthy matrix renewal.

04

Antioxidant Defense

Laboratory and preclinical research describes antioxidant and inflammation-modulating activity that may help support the skin’s response to environmental stress.

Research references

Pickart L, Margolina A. Regenerative and Protective Actions of the GHK Peptide in the Light of the New Gene Data. International Journal of Molecular Sciences. 2018.

Dou Y, Lee A, Zhu L, Morton J, Ladiges W. The potential of GHK as an anti-aging peptide. Aging Pathobiology and Therapeutics. 2020.

Pickart L, Vasquez-Soltero JM, Margolina A. GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration. BioMed Research International. 2015.

Maquart FX, Pickart L, Laurent M, Gillery P, Monboisse JC, Borel JP. Stimulation of collagen synthesis in fibroblast cultures by the tripeptide-copper complex glycyl-L-histidyl-L-lysine-Cu2+. FEBS Letters. 1988.

Research discussed in this section evaluates GHK or GHK across laboratory, ex vivo, preclinical and human cosmetic settings. These studies did not evaluate the finished Alchemy 21/12 GHK Night Cream. Individual results may vary.

THE COPPER SIGNAL

GHK Night Cream, explained.

What GHK is, how it fits into the ritual, and how to protect the formula's performance.

What is GHK?

GHK is a naturally occurring copper-binding tripeptide composed of glycine, histidine, and lysine. In skincare research, it has been studied for its role in processes associated with visible recovery, extracellular-matrix support, collagen production, antioxidant defense, and tissue remodeling.

In GHK Night Cream, it functions as a concentrated nighttime signal inside a complete barrier-supportive formula.

Will I purge?

I am starting you right off with the first question to address. The answer is, it depends. The majority of those that use our GHK Night Cream tolerate it beautifully and never once see a visible sign of a purge. That is by design. Both our formula and our education on how to introduce it is intentionally directed at the easiest-to-tolerate response.

Strong purge events or worsening conditions of the skin are not normal when using GHK. We have seen a massive uptick in searches and conversations around the phenomenon, the Copper Uglies. This is not an intended or recommended outcome for GHK and should NOT be accepted as the natural result from using it.

A significant amount of the conversation appears to be coming from the injection community, very high-strength topical products, or users layering multiple GHK products at the same time and unintentionally compounding their total exposure.

Mild periods of adjustment can happen, and with a well-formulated product and a measured introduction, they should be transient, manageable, and often barely perceptible.

I go through periods of correction as I use this product and have learned to use it as a tool, rather than a process to push through. Once I start to see evidence of a correction (typically for me, it's more redness and mild irritation in parts of my face and breakouts on my forehead), I back off. The start of a correction cycle is my sign that the product has entered its signal + repair cycle.

At this point, I typically stop using the cream for at least a week to allow that cycle to run its natural course. I find this is the most mild way to introduce and maintain this product. Once you have introduced it and understand how your skin reacts, you can add additional nights or take recovery breaks as needed. But most people find that after a few weeks, their skin adapts quickly and they are able to assume nightly or every-other-night application.

THAT is what a well-formulated GHK product should deliver. ACCEPT NOTHING LESS.

GHK is powerful. It is effective. And, like all of these products, when used optimally, will truly transform your skin. If you have any concerns or questions at all while using this product, email us cs@alchemy2112.com and we will guide you.

What does GHK Night Cream do for the look of skin?

GHK Night Cream is designed for skin that looks depleted, less firm, uneven in texture, or slower to recover. Its copper-peptide signal is paired with ectoin, niacinamide, panthenol, and a cushioned emollient system to help skin look smoother, stronger, more resilient, and visibly restored over time.

Why is the cream blue?

The blue color comes naturally from the copper-peptide complex. It is not an added dye, and it does not mean the formula has oxidized.

The color should disappear as the cream is spread into a thin, even layer.

Why did Alchemy 21/12 use 0.25% GHK?

We use GHK at 0.25% as a deliberate, concentrated nighttime signal within a complete barrier-supportive cream. More is not automatically better with signaling ingredients.

The goal is a meaningful amount in a balanced formula that skin can use consistently, rather than building the product around the highest possible number.

Why should GHK Night Cream be refrigerated?

GHK Night Cream should be stored in the refrigerator to help preserve the finished formula's intended stability and performance.

Keep it chilled, close the container promptly after use, and avoid leaving it in direct light or prolonged heat.

When should I use it?

Once you fully understand and have become acclimated to GHK, you will use GHK Night Cream in the evening as the final step of your nighttime ritual. Start off with 1-2x per week on opposite nights you are using CORRECTV. Once you feel you are tolerating both well, you may then combine them up to nightly use, as tolerated.

Cleanse → Toner → Recover-Me 3S CORRECTV Complex → GHK Night Cream.

Allow the preceding serum layer to settle before applying the cream.

How much should I apply?

Begin with one pump for the face and add a small amount for the neck and décolletage as needed.

More product does not create a stronger copper-peptide signal. A thin, even layer is enough.

Can I use GHK Night Cream every night?

Yes, once your skin has adjusted to it. If your skin is reactive, or if you are introducing several concentrated Alchemy formulas at the same time, begin two or three evenings weekly and increase according to comfort.

Can sensitive skin use copper peptides?

Many people tolerate topical copper peptides well, but any concentrated active can cause redness, itching, or irritation in some skin.

Patch test first, introduce the cream gradually, and stop using it if you experience persistent discomfort, swelling, or a worsening reaction.

Can I use it with vitamin C or exfoliating acids?

We recommend separating GHK Night Cream from strongly acidic L-ascorbic acid and low-pH exfoliating treatments.

Use vitamin C in the morning. Use Enzyme + PHA Resurfacing Polish on a separate evening. This keeps the ritual more controlled and avoids creating an unnecessarily reactive routine.

Is GHK Night Cream a moisturizer or a treatment?

It is both. The formula delivers a concentrated copper-peptide signal inside a night cream that also replenishes hydration and supports the lipid barrier.

That matters because signaling is only one part of visible recovery. Skin also needs water, lipids, and a stable environment in which to respond.

How is it different from Recover-Me Barrier Cream?

Recover-Me Barrier Cream is the daily barrier moisturizer. It focuses on replenishing moisture, reducing water loss, and maintaining calm, comfortable resilience.

GHK Night Cream is the more concentrated nighttime intervention. It adds the GHK signal to barrier and hydration support for skin showing more visible loss of firmness, texture refinement, or recovery capacity.

Barrier Cream protects the conditions. GHK Night Cream adds the nighttime signal.

How is it different from Recover-Me 3S CORRECTV Complex?

CORRECTV is a concentrated nighttime serum built around PDRN, Camellia-derived extracellular vesicles, and a multi-peptide corrective stack.

GHK Night Cream completes the ritual with copper-peptide signaling, ectoin, niacinamide, panthenol, and a cushioned emollient system. CORRECTV delivers the first corrective layer. GHK seals the ritual and adds its own distinct signal.

How long before I see results?

You may notice greater softness, hydration, and comfort within the first several uses. Visible improvements in firmness, texture, resilience, and the appearance of fine lines develop more gradually.

Human studies of topical GHK creams reported measurable improvements after 12 weeks of consistent use, including improvements in skin density, firmness, laxity, fine lines, and wrinkle depth.

Give the ritual 8 to 12 weeks to show you what it can do.

These studies evaluated GHK-containing creams rather than the finished Alchemy 21/12 formula. Individual results will vary.

Will it turn my skin blue?

No. The cream's blue color comes from the copper-peptide complex, but it should disappear as the product is spread into a thin, even layer.

Applying substantially more than directed may leave unnecessary visible residue.

Can I use it around my eyes?

Apply around the orbital bone rather than directly against the lash line or onto the eyelids. Avoid contact with the eyes.

If your eye area is highly reactive, introduce it cautiously.

Can I use it after professional treatments?

Do not assume that a concentrated peptide cream is appropriate immediately after a laser, peel, microneedling procedure, injectable treatment, or any procedure that temporarily compromises the skin.

Follow your practitioner's post-treatment instructions and reintroduce GHK Night Cream only after they have cleared active skincare.

Can I use it during pregnancy or breastfeeding?

Topical cosmetic copper peptides do not have a robust pregnancy-specific safety evidence base. Ask your obstetrician or medical provider before beginning any concentrated active product during pregnancy or breastfeeding.

  • 5 stars: 41 (98%)
  • 4 stars: 1 (2%)
  • 3 stars: 0 (0%)
  • 2 stars: 0 (0%)
  • 1 star: 0 (0%)
C
Calandria P.

I love the GHK Night Cream from Alchemy2112 — it's made my skin look so much healthier. The best part is that since using the entire ritual, my skin looks amazing. I had a pimple, and it went away smoothly. As we know, when pimples go away, they usually leave marks behind — but OMG, after using the Alchemy2112 ritual beauty set, no pimple marks! My skin has an even tone. I definitely recommend the entire Alchemy2112 beauty set.

K
Kelley S.
Absolutely transformed my skin.

I've never seen changes like this in my skin from a topical. My skin is brighter, clearer, and firmer all over and my melasma is non-existent. It took some time to get used to using the product, and I took it very slow. I even took a week off when I traveled and I still continued to have day to day changes. I use it 2-3 times a week now for maintenance.

J
Jennifer A.
My Skin Needed Support, Not More Aggression

I received this product in exchange for my honest review. This gives me a focused night treatment without the burn, peel, or morning damage I’d learned to expect from “serious” skincare. It took a bit to get used to the color, but then after I was used to it, it was a non-issue. I was just worried it might leave a residue or stain and it doesn't at all.

L
Luz A.
A More Resilient Look by Morning

My skin looks more resilient by morning, especially after nights when it started out tired and depleted. The cheek area appears better supported and the surface looks less fragile. The result is subtle, but it changes the whole expression of the face.

A
Alice V.

This has given me better results than any face cream I have used. Paired with the Recover Serum, it has made my skin feel firmer, softened the wrinkles around my mouth, and brought back a noticeable glow. Five stars and an easy recommendation.

J
Jacqueline P.
A Night Treatment My Mature Skin Can Live With

My mature skin can live with this night treatment. It feels nourishing and focused without creating the morning redness or dryness I’ve experienced with more aggressive routines. The cream gives me correction I can actually repeat.

F
Fernanda K.

After the rest of my routine, this feels like the final layer that seals everything in. It keeps my skin smooth, hydrated, comfortable, and protected. I'm excited to see my results after 12 weeks of use!

T
Thandiwe G.
GHK Replaced My Night Cream

GHK replaced my ordinary night cream because it gives that final step a more specific purpose. I’m still getting moisture and comfort, but the copper-peptide focus makes the routine feel corrective rather than merely rich. I use Barrier Cream on other nights and choose this when I want the deeper signal.

E
Erin G.

I truly love this cream. It gives my skin lasting hydration and leaves it feeling silky soft. I can already see an improvement in my complexion, and I am excited to see how the results build with continued use.

R
Rosario L.
Correction Without the Morning Regret

This gives me correction without the morning regret. My mature skin wakes up soft and composed instead of red, dry, or obviously overtreated. I can pursue smoother, firmer-looking skin without making irritation the proof that something happened.

P
Paloma E.

I have tested so many skincare products over the years, and I know it sounds cliché, but this one truly feels different. The texture, performance, and way my skin responds set it apart from everything else I have used.

P
Pamela R.
When My Skin Looks as Tired as I Feel

I have tried nearly everything over the years, including products and treatments recommended by dermatologist influencers, so I was skeptical. I initially receied this through a marketing promotion and have now received it twice for free from the founder. It is the ideal renewal cream: lightweight in feel but richly moisturizing, and it fits perfectly into my routine after cleansing and after my serums. I started slow the first week and then went for it the second week. I noticed a near immediate reaction from my skin that it was starting to turn over and repair. I backed off on the third week to 3x a week and that was the sweet spot. My melasma spots have faded, my skin looks bright and youthful and so far I have not experienced any major down time or irritation from the renewal strength. I think it is worth the price even without a discount.

A
Araceli N.
A Better Overnight Moisture Finish

This gives me a better overnight moisture finish than a standard heavy cream. My skin wakes up soft and cushioned, but there’s no greasy film waiting to be washed off. The comfort feels integrated into the skin rather than sitting on top.

B
Brittany Q.
The Color Made Me Curious, the Finish Made Me Stay

The color made me curious, but the finish made me stay. The natural blue tone is striking in the hand, then disappears into a soft, silky layer on the skin. I wake up comfortable, not coated. That combination of visual identity and practical performance is very hard to forget.

H
Holly L.
Copper Peptide Care Without a Clinical Feel

Copper-peptide care can sound clinical. This doesn’t feel that way. The cool blue cream is elegant, comfortable, and easy to make part of a real night routine. The technology is serious, but the experience is beautiful.

D
Deja J.
The Firmness Change Was Gradual but Clear

The firmness change was gradual but clear. After several weeks, the skin across my cheeks looked less flat and more supported, especially in side light. It wasn’t a tightening sensation and it didn’t arrive after one dramatic night. The improvement built quietly alongside smoother texture and better morning softness. That combination feels much more convincing to me than a product promising an instant lift.

C
Catalina Q.
A More Refined Morning Face

My face looks more refined in the morning after consistent use. The surface across the cheeks is smoother, and fine texture doesn’t catch the light as sharply. I’m not waking up with a filtered face... just a better version of my actual skin.

L
Lucy N.
The Morning Softness Is Immediate

The morning softness is immediate. My skin feels cushioned when I wake up, especially across the cheeks and around the mouth. The smoother, firmer-looking changes take longer, but the overnight comfort shows up from the first use.

M
Mariana D.
The Night Cream for Weeks That Show on My Face

I am an EMT and some weeks show on my face no matter how well I sleep. Stress leaves the surface dull, the cheeks flat, and every line a little more obvious. GHK has become the final step I use when my skin looks as depleted as I feel. The cream is cool and comforting on contact, and I wake up softer immediately. With consistency, my face also looks smoother and more resilient after those demanding stretches.

A
Angela U.
The Ingredient Story Held Up in Use

The ingredient story held up in use. I bought the cream because of GHK-Cu, but I kept using it because the base makes the copper peptide easy to live with. The formula is cool, silky, and comforting, not austere or medicinal. Over time, my skin has looked smoother and better supported without peeling or visible stress. The technology and the texture are serving the same goal, which is rarer than it should be.

S
Shirley Y.
The GHK-Cu Is the Reason I Bought It

The GHK-Cu is the reason I bought it. I wanted a true copper-peptide formula surrounded by enough hydration and emollience to make nightly use comfortable. That’s exactly what this is. The cream feels elegant, and the longer-term texture changes have justified the ingredient interest.

D
Dolores G.

I replaced the 72-hour hyaluronic moisturizer I had loved for years with this cream, and I am so glad I did. This formula suits my skin even better, and it has quickly become my new favorite.

N
Natalie B.
The Refrigerator Requirement Is Manageable

The refrigerator requirement is manageable. I keep it beside the products I use at night, retrieve it while CORRECTV is setting, and put it back when I’m done. It became a habit in less than a week.

M
Margaret W.

This cream has made a real difference in the look and feel of my skin. My face and hands are softer and smoother, and I have noticed less dryness and fewer visible wrinkles. The peptide-rich formula seems to give my skin exactly the boost it needed.

R
Rocío C.
Lighter Than I Expected From a Night Cream

This is much lighter than I expected from a serious night cream. It has enough richness to leave my skin cushioned, but it doesn’t feel like a thick sleeping mask. The cream spreads easily and settles without a greasy layer on the pillow.

E
Ellen I.
A More Composed Morning After a Hard Day

After a hard day, this helps me wake up looking more composed. The cream softens the depleted texture immediately, and my cheeks look less flat by morning. It’s become the night step I choose when stress is written all over my face.

P
Phoebe S.
A Night Cream With a Real Point of Difference

This night cream has a real point of difference. The GHK-Cu is the reason for the formula, not a decorative ingredient buried in an ordinary moisturizer. I get immediate overnight comfort and a smoother, better-supported look that has built gradually with use.

G
Grace Y.
The Blue Is Part of the Formula

The blue is part of the formula, and I love that it hasn’t been hidden or corrected for presentation. The color comes from the copper peptide and makes the cream feel honest about what it is. I apply two or three pumps as my final evening step, and the blue disappears as the cream spreads. What remains is a cool, silky layer with no artificial color story attached. It looks unusual in the best possible way... technically beautiful rather than cosmetically decorated.

F
Fatima P.
A Naturally Beautiful Night Cream

This is a naturally beautiful night cream. The blue tone is distinctive, the refrigerated texture feels luxurious, and none of it relies on added fragrance or decorative color. I can see the copper peptide identity before I even apply it. Once spread, the color disappears and the finish becomes soft and refined. The beauty is connected to the formula rather than added around it, which makes the entire experience feel more authentic. I received this product in exchange for my honest review.

I
Isabela A.
A Treatment Cream Without the Thick Mask

GHK feels like a treatment cream without the thick mask. The texture has body and cushion, but it doesn’t sit heavily on my face or transfer everywhere overnight. I use two or three pumps and let the cream spread rather than piling on extra. The morning finish is soft and comfortable, while the smoother-looking surface has appeared gradually. It gives me the seriousness of a focused treatment in a texture I actually enjoy.

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