ESSENTIALS II COLLECTION

$676.00

$498.00

ESSENTIALS II COLLECTION

Name: ESSENTIALS II COLLECTION
Brand: Alchemy 21/12
Price: 498.00 USD
Availability: InStock

The Alchemy 21/12 Complete Ritual

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$676.00

$498.00

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The complete seven-step Alchemy Ritual for cleansing, resurfacing, layered hydration, regenerative signaling, barrier support, and overnight renewal.

What’s included

Barrier Cleanser
Recover-Me EGCG + PAD Toner
Enzyme + PHA Resurfacing Polish
Crystal PDRN Glass Serum
Recover-Me 3S Serum
Recover-Me Barrier Cream
GHK Night Cream

Essentials II brings the full morning-to-night ritual together in one comprehensive system. The seven formulas work in sequence to cleanse gently, refine texture, replenish hydration, support visible renewal, reinforce the barrier, and complete the routine with copper peptide-powered overnight care.

Used together, they help skin look smoother, calmer, stronger, more luminous, and visibly renewed over time.

Quantity

WHAT IT DOES

Essentials II is built around intentional layering rather than one overloaded formula. Each step performs a distinct function within the system:

Cleanse without compromising comfort.
Refine without harsh abrasion.
Hydrate through multiple water-binding pathways.
Signal through peptides, PDRN, exosomes, and GHK-Cu.
Strengthen with biomimetic barrier support.
Renew through a dedicated overnight treatment.

Together, the formulas support both the immediate appearance of the skin and the biological pathways associated with long-term resilience and visible regeneration.

WHY IT WORKS

COMPLETE AM + PM SYSTEM
Seven complementary formulas designed to work in sequence.

MULTI-PATHWAY SIGNALING
Peptides, PDRN, exosomes, and GHK-Cu support visible renewal.

BARRIER-FIRST DESIGN
Every treatment is balanced with hydration, comfort, and resilience.

DAY-TO-NIGHT SUPPORT
Lightweight daily layers transition into concentrated overnight renewal.

HOW TO USE

Daily | Morning + Evening

Morning

1. Cleanse
Massage Barrier Cleanser onto damp skin and rinse thoroughly.

2. Hydrate
Mist Recover-Me Hydrating Toner over clean skin or press it in with your hands.

3. Layer hydration
Apply Crystal PDRN Glass Serum.

4. Signal
Follow with Recover-Me 3S Serum.

5. Seal
Finish with Recover-Me Barrier Cream and sunscreen.

Evening

Repeat the cleanse, toner, Crystal, and Recover-Me 3S Serum steps.

Finish with either:

Recover-Me Barrier Cream for lightweight barrier support, or GHK Night Cream for concentrated overnight copper peptide therapy.

One to three times weekly

Use Enzyme + PHA Resurfacing Polish after cleansing and before toner. Apply a thin, even layer, allow it to work as directed, rinse thoroughly, then continue the ritual.

Ritual order:

Cleanse → Polish → Hydrate → Layer → Signal → Strengthen → Renew

Pairs well with

AHK PEPTIDE HAIR & SCALP SERUM

$148.00

COTTON CANVAS GO-BAG

$34.00

ESSENTIALS II COLLECTION

For Skin Experiencing

A complete day-to-night ritual for skin showing the visible effects of dehydration, stress, barrier depletion, and changing skin function over time.

Loss of Firmness

Uneven Texture & Tone

Fine Lines

Barrier Disruption

Needs a reset

Visible Signs of Aging

Hydrate

206.55%

More of a key water-holding protein

Measured: filaggrin expression

Red Ginseng PDRN

The foundation remains

Intensive correction still begins with water skin can hold.

Essentials II preserves the same hydration architecture as Essentials I. Red ginseng PDRN increased proteins involved in water retention and epidermal cohesion in ex-vivo skin, creating the conditions concentrated signaling needs to work within.

206.55% More of a key water-holding protein Filaggrin · ex vivo

154.47% More of a key barrier-sealing protein Claudin-1 · ex vivo

See what was measured

In supplier ex-vivo testing, RG PDRN 1000 at the tested 1% concentration increased filaggrin expression by 206.55% and claudin-1 expression by 154.47% versus untreated tissue.

Filaggrin contributes to formation of the outer skin layer and natural moisturizing factors. Claudin-1 helps maintain tight junctions between epidermal cells.

Source: CoSeedBioPharm RG PDRN 1000 efficacy dossier, 2026.

Calm

21.7%

Lower expression of a heat-stress response receptor

Measured: PAR-2 expression in heat-stressed skin cells

Camellia Extracellular Vesicles

Four routes into visible calm

Redness is only the part of the stress response you can see.

Camellia extracellular vesicles target a heat-stress response receptor. PAD addresses visible erythema. PT-8 helps quiet an irritation-associated heat response. EGCG supports antioxidant defense against stress pathways that can keep skin looking red and reactive.

21.7% Lower expression of a heat-stress response receptor Camellia EVs · in vitro

95% Facial erythema disappeared at follow-up PAD formula · human study

78% Lower irritation-associated heat response PT-8 formula · human challenge

51% Lower expression of a visible stress-response marker EGCG formula · human tissue

See what was measured

Camellia extracellular vesicles: In supplier testing, EXO-CAMELLISOME reduced PAR-2 expression by 21.7% in heat-stressed HaCaT keratinocytes. The raw material was characterized at an average particle size of 122.8 nm and approximately 9.27 × 10⁸ particles per milliliter.

PAD: In a randomized, double-blind, placebo-controlled pilot study, a cream containing 5% potassium azeloyl diglycinate plus 1% hydroxypropyl chitosan was used twice daily for four weeks. Clinical inspection reported facial erythema disappearing in 95% of treated participants by day 42.

PT-8: In a 13-person SDS challenge, a formula containing Palmitoyl Tripeptide-8 reduced the irritation-associated skin-temperature rise by 78% when applied after the challenge.

EGCG: In a four-person split-face study, a 2.5% EGCG cream reduced HIF-1α-positive epidermal staining from 28.4% to 13.8%, a 51.4% relative reduction, after six weeks.

The published human studies used different finished formulas, concentrations, and delivery systems than Essentials II.

Camellia EV source: CoSeedBioPharm EXO-CAMELLISOME dossier, 2025. PAD study PT-8 study EGCG study

Strengthen

5.5 YEARS

Equivalent gain in measured anti-wrinkle efficacy

Supplier result after two months

Matrixyl 3000 · PT-5 · GHK-Cu

Build more. Protect what gets built.

A coordinated strategy for the skin-supporting matrix.

Matrixyl 3000 supplies matrikine signaling associated with dermal repair. PT-5 supports collagen-linked wrinkle improvement. GHK-Cu couples a tripeptide signal with copper and has shown a measurable human procollagen response.

5.5 years Equivalent gain in anti-wrinkle efficacy after two months Matrixyl 3000 · supplier testing

70% Of treated women showed increased collagen production GHK-Cu · human biopsy study

24.78% Smaller facial wrinkles versus untreated skin PT-5 formula · human study

See what was measured

Matrixyl 3000: Croda reports anti-wrinkle efficacy equivalent to an age gain of approximately two years after one month and up to 5.5 years after two months in supplier testing of its branded Palmitoyl Tripeptide-1 and Palmitoyl Tetrapeptide-7 complex.

GHK-Cu: In a one-month active-controlled study of 20 participants, topical GHK-Cu increased procollagen synthesis in 7 of 10 treated women, compared with 5 of 10 using vitamin C and 4 of 10 using retinoic acid.

PT-5: A 20-person split-face thesis study reported a 24.78% reduction in facial wrinkle size versus untreated skin with a cream containing Palmitoyl Tripeptide-5. The formula differed from Recover-Me 3S, and the same research did not detect measurable PT-5 uptake or penetration in its separate in-vitro skin model.

These findings reflect separate ingredient or finished-formula studies and do not establish the performance of Essentials II as a completed system.

Matrixyl 3000 supplier data GHK-Cu study PT-5 study

Signal

147.29%

More collagen type I expression

Measured in ex-vivo skin

PDRN · AH-8 · Camellia EVs · Peptides · GHK-Cu

Multiple signals. Distinct pathways.

Signaling designed to work in more than one language.

PDRN supplies nucleotide-related renewal support. AH-8 targets the visible expression-line pathway. Camellia extracellular vesicles act as nanoscale intercellular messengers. Matrixyl 3000, PT-5, and GHK-Cu add complementary matrix and collagen signaling.

147.29% More collagen type I expression Red ginseng PDRN · ex vivo

58.75% Less expression of a collagen-breakdown enzyme MMP-1 · in vitro

48.9% Total anti-wrinkle efficacy AH-8 formula · human study

8.6% More growth of epidermal skin cells Camellia EVs · in vitro

See what was measured

Red ginseng PDRN: Supplier testing reported a 147.29% increase in collagen type I expression in ex-vivo skin at the tested 1% concentration, 58.75% inhibition of MMP-1 expression at 0.3%, and a 28.54% increase in fibroblast migration at 0.3%.

AH-8: In a randomized, placebo-controlled study of 60 participants, topical Argireline / Acetyl Hexapeptide-8 produced 48.9% total anti-wrinkle efficacy after four weeks, compared with 0% for placebo.

Camellia extracellular vesicles: Supplier testing reported an 8.6% increase in HaCaT keratinocyte proliferation. Particle analysis characterized the raw material at an average size of 122.8 nm and approximately 9.27 × 10⁸ particles per milliliter.

The AH-8 study used a different finished formula and concentration than Recover-Me 3S. Exosome and PDRN findings reflect supplier ingredient-level testing.

PDRN source: CoSeedBioPharm RG PDRN 1000 efficacy dossier, 2026. Camellia EV source: CoSeedBioPharm EXO-CAMELLISOME dossier, 2025. AH-8 study

Percentages shown reflect ingredient-level in-vitro, ex-vivo, supplier, or published human research conducted at the concentrations and in the vehicles identified in each study detail. Essentials II has not been clinically tested as a finished system, and these findings do not predict individual results.

THE ESSENTIALS II COLLECTION

The complete regenerative ritual.

Seven complementary formulas designed to cleanse, resurface, replenish, treat, repair, seal, and support visible renewal from morning through night.

THE COMPLETE SYSTEM

Every essential function, covered.

Essentials II expands the daily foundation into a complete day-to-night system for skin showing the visible effects of dehydration, stress, barrier depletion, and changing skin function over time.

Barrier Cleanser removes daily buildup without leaving skin tight or depleted.

Enzyme Polish provides periodic resurfacing to help lift dull buildup and refine the look of texture.

Recover-Me EGCG + PAD Toner replenishes hydration while supporting visible calm, balance, and antioxidant defense.

Crystal PDRN Glass Serum delivers immediate, moisture-binding hydration to smooth the look of dehydration and restore luminosity.

Recover-Me 3S Serum adds PDRN, peptides, and exosomes to support visible renewal, resilience, and stronger-looking skin over time.

Barrier Cream seals in moisture with barrier-supportive lipids and replenishing actives to help preserve softness and comfort.

GHK Night Cream completes the evening ritual with copper peptide technology and barrier-supportive actives designed to support overnight repair and visible regeneration.

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